Impact of gestational bisphenol A on oxidative stress and free fatty acids: Human association and interspecies animal testing studies.

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TitleImpact of gestational bisphenol A on oxidative stress and free fatty acids: Human association and interspecies animal testing studies.
Publication TypeJournal Article
Year of Publication2015
AuthorsVeiga-Lopez A, Pennathur S, Kannan K, Patisaul HB, Dolinoy DC, Zeng L, Padmanabhan V
JournalEndocrinology
Volume156
Issue3
Pagination911-22
Date Published2015 Mar
ISSN1945-7170
KeywordsAdult, Animals, Benzhydryl Compounds, Biological Markers, Environmental Pollutants, Fatty Acids, Nonesterified, Female, Fetal Blood, Fetus, Humans, Hypopituitarism, Maternal Exposure, Mice, Oxidative Stress, Phenols, Pregnancy, Rats, Species Specificity
Abstract

Bisphenol A (BPA) is a high production volume chemical and an endocrine disruptor. Developmental exposures to BPA have been linked to adult metabolic pathologies, but the pathways through which these disruptions occur remain unknown. This is a comprehensive interspecies association vs causal study to evaluate risks posed by prenatal BPA exposure and to facilitate discovery of biomarkers of relevance to BPA toxicity. Samples from human pregnancies during the first trimester and at term, as well as fetal and/or adult samples from prenatally BPA-treated sheep, rats, and mice, were collected to assess the impact of BPA on free fatty acid and oxidative stress dynamics. Mothers exposed to higher BPA during early to midpregnancy and their matching term cord samples displayed increased 3-nitrotyrosine (NY), a marker of nitrosative stress. Maternal samples had increased palmitic acid, which was positively correlated with NY. Sheep fetuses and adult sheep and rats prenatally exposed to a human-relevant exposure dose of BPA showed increased systemic nitrosative stress. The strongest effect of BPA on circulating free fatty acids was observed in adult mice in the absence of increased oxidative stress. This is the first multispecies study that combines human association and animal causal studies assessing the risk posed by prenatal BPA exposure to metabolic health. This study provides evidence of the induction of nitrosative stress by prenatal BPA in both the mother and fetus at time of birth and is thus supportive of the use of maternal NY as a biomarker for offspring health.

DOI10.1210/en.2014-1863
Alternate JournalEndocrinology
PubMed ID25603046
PubMed Central IDPMC4330308
Grant ListP01 ES022844 / ES / NIEHS NIH HHS / United States
P30 DK020572 / DK / NIDDK NIH HHS / United States
P30 DK089503 / DK / NIDDK NIH HHS / United States
P30 ES017885 / ES / NIEHS NIH HHS / United States
P30DK089503 / DK / NIDDK NIH HHS / United States
P30ES017885 / ES / NIEHS NIH HHS / United States
R01 ES016001 / ES / NIEHS NIH HHS / United States
R01 ES016541 / ES / NIEHS NIH HHS / United States
R01 ES017005 / ES / NIEHS NIH HHS / United States
R01 ES017524 / ES / NIEHS NIH HHS / United States
U24 DK097153 / DK / NIDDK NIH HHS / United States