Adipose fatty acid oxidation is required for thermogenesis and potentiates oxidative stress-induced inflammation.

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TitleAdipose fatty acid oxidation is required for thermogenesis and potentiates oxidative stress-induced inflammation.
Publication TypeJournal Article
Year of Publication2015
AuthorsLee J, Ellis JM, Wolfgang MJ
JournalCell Rep
Volume10
Issue2
Pagination266-79
Date Published2015 Jan 13
ISSN2211-1247
Abstract

To understand the contribution of adipose tissue fatty acid oxidation to whole-body metabolism, we generated mice with an adipose-specific knockout of carnitine palmitoyltransferase 2 (CPT2(A-/-)), an obligate step in mitochondrial long-chain fatty acid oxidation. CPT2(A-/-) mice became hypothermic after an acute cold challenge, and CPT2(A-/-) brown adipose tissue (BAT) failed to upregulate thermogenic genes in response to agonist-induced stimulation. The adipose-specific loss of CPT2 resulted in diet-dependent changes in adiposity but did not result in changes in body weight on low- or high-fat diets. Additionally, CPT2(A-/-) mice had suppressed high-fat diet-induced oxidative stress and inflammation in visceral white adipose tissue (WAT); however, high-fat diet-induced glucose intolerance was not improved. These data show that fatty acid oxidation is required for cold-induced thermogenesis in BAT and high-fat diet-induced oxidative stress and inflammation in WAT.

DOI10.1016/j.celrep.2014.12.023
Alternate JournalCell Rep
PubMed ID25578732
PubMed Central IDPMC4359063
Grant ListR01 NS072241 / NS / NINDS NIH HHS / United States
R01NS072241 / NS / NINDS NIH HHS / United States
U24 DK097153 / DK / NIDDK NIH HHS / United States