Serum Cortisol-to-Cortisone Ratio and Blood Pressure in Severe Obesity before and after Weight Loss.

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TitleSerum Cortisol-to-Cortisone Ratio and Blood Pressure in Severe Obesity before and after Weight Loss.
Publication TypeJournal Article
Year of Publication2015
AuthorsByrd JB, Rothberg AE, Chomic R, Burant CF, Brook RD, Auchus RJ
JournalCardiorenal Med
Volume6
Issue1
Pagination1-7
Date Published2015 Dec
ISSN1664-3828
Abstract

BACKGROUND/AIMS: The pathogenesis of obesity-associated hypertension is poorly understood. Serum cortisol-to-cortisone ratio (F/E ratio) is a marker of cortisol metabolism. Our objective was to determine whether the serum F/E ratio is associated with blood pressure (BP) in patients after significant weight loss (≥15% from baseline weight).METHODS: Sera from 43 nondiabetic, severely obese males participating in a weight management program were assayed for F and E by mass spectrometry. We assessed whether changes in the F/E ratio accompanying weight loss correlate with changes in the systolic (SBP) and diastolic BP (DBP). Linear regression was used to evaluate change in the F/E ratio as a predictor of change in BP.RESULTS: The body mass index decreased from 40.8 ± 5.6 to 33.7 ± 4.8 (p < 0.001); also, SBP (133.2 ± 13.8 vs. 124.1 ± 14.3 mm Hg; p < 0.001) and DBP (69.8 ± 8.0 vs. 66.6 ± 9.4 mm Hg; p = 0.026) decreased during the study. The baseline F/E ratio tended to associate with baseline DBP (Spearman's r = -0.29, p = 0.06), and change in the serum F/E ratio correlated with change in DBP (Spearman's r = -0.32, p = 0.036). Change in the F/E ratio also tended to associate with change in SBP (Spearman's r = -0.27, p = 0.08). A multiple linear regression model adjusted for change in the F/E ratio and age explained 22% of the variance in SBP change (R(2) = 0.22, p = 0.007). Change in the F/E ratio independently predicted change in SBP (p = 0.036).CONCLUSION: In our sample of nondiabetic, severely obese males, change in the serum F/E ratio was associated with change in BP after weight loss.

DOI10.1159/000438462
Alternate JournalCardiorenal Med
PubMed ID27194991
PubMed Central IDPMC4698606