Welcome to MRC2 at the University of Michigan

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News

  • August 26, 2014 VIDEO: "Some cells know how to keep their secrets" (University of Florida -- Gainesville)
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  • July 17, 2014 The National Institutes of Health (NIH) has awarded a $100,000 supplemental grant to Dr. Kestas Bedinskas at the Molecular Biology and Biochemistry Center (MBBC) at SUNY Oswego to collaborate with the MRC2 in defining the effect of Exposed to Low-Level Environmental Heavy Metals in Children.
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  • June 10, 2014MRC2 2014 P/F Grant Awardees: Jaspreet Singh, Ph.D.; Laura den Hartigh, Ph.D.; Craig L. Hanis, Ph.D.; Elizabeth K. Speliotes, M.D., Ph.D., M.P.H.; and Jason Michael Tennessen, Ph.D.
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Events

  • March 19, 2015 - 1pm MRC2 Seminar: Kestas Bendinskas (SUNY - Oswego)
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  • April 2, 2015 - 1pm MRC2 Seminar: Jeff McDonald (UTSouthwestern)
  • May 14, 2015 - 1pm MRC2 Seminar: Robert Gerszten (Harvard) - "Come on BAIBA light my fire: Mining the Blood for New Cardiometabolic Hormones" Read more » | RSVP
  • June 15-18, 2015 Metabolomics Summer Workshop
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OVERVIEW

MRC2 Team

Front row: Jan Wigginton, Grace Wu, Jane Cao, Alla Karnovsky, Kari Bonds, Terri Ridenour/Back row: Li Zhang, Jaeman Byun, Maureen Kachman, Sub Pennathur, Sasha Raskind, Chuck Burant, Bill Duren, Tanu Soni, Robert Chomic, Heidi Baum, TM Rajendiran/Not pictured: Arun Das, Charles Evans and Chunhai Ruan

The Michigan Regional Comprehensive Metabolomics Resource Core (MRC)2 aims to improve diagnosis, prevention and monitoring of many diseases through metabolic profiling. The metabolome is the sum of all metabolites at a given moment. Profiling gives a chemical readout of the state of health of the cell or body and its changes. These results provide a wealth of information about nutrition, infection, health and disease status.

Directed by Charles Burant, MD, PhD MRC2 is one of six metabolomics centers in the United States funded by the National Institutes of Health (NIH) Common Fund.

The MRC2 provides

  • Comprehensive laboratory services
  • Consultations
  • Educational seminars
  • Workshops
  • Online videos
  • Funding for investigators through Pilot and Feasibility grants

Laboratory Services

  • Lipidomics
  • Targeted Metabolomics – Fluxomics
  • Untargeted Metabolomics

Click here for more information about services and fees

Technology
MRC2 state-of-the-art technology, includes:

  • Multiple high-resolution, high mass accuracy qTOF
  • High sensitivity triple-quad instruments for LC/MS
  • Mass unit resolution instruments for GC/MS
  • A laboratory information management system (MetLIMS) that captures study metadata, study samples, sample processing history and final results
  • A bioinformatics and mathematical modeling infrastructure that visualizes and models complex omics level interactions with the phenotype

Consultation
The MRC2 offers expertise in:

  • designing and executingmetabolomics studies
  • determining appropriate uses of technology and in-depth statistical analyses
  • analyzing results with bioinformatics tools and statistics

Data sharing
The MRC2 contributes to the UCSD Metabolomics Workbench website, overseen by the Data Repository and Coordinating Center (DRCC), Metabolomics Workbench site provides data-sharing standards for metabolomics experiments and access to data sets by the research community. Data sharing includes

  • Primary raw data
  • Interpretive biological and analytical meta-data . 

Acknowledgement
NIH Public Access Policy requires that all publication that results from NIH funding be uploaded to PubMed Central. Review the process for uploading publications.
It is extremely important that our grant is cited in all publications resulting from the use of MRC2 services. Our productivity and effectiveness as a Core is measured in part by the citation of the grant in published work. Please use the following acknowledgement in your publications:
This work utilized Core Services supported by grant DK097153 of NIH to the University of Michigan.

For a comprehensive listing, please visit our publications page.

Research Acknowledgement

It is extremely important that our grant is cited in all publications resulting from the use of MRC2 services. Our productivity and effectiveness as a Core is measured in part by the citation of the grant in published work. Please use the following acknowledgement in your publications:

This work utilized Core Services supported by grant DK097153 of NIH to the University of Michigan.