Cure Room (5050 Brehm Tower), 1000 Wall Street, Ann Arbor
Daniel Raftery, PhD
Advanced Methods Development in Metabolomics and Applications to Colon Cancer
Dr. Daniel Raftery is the NORC Metabolomics Sub-Core Facility Director and Department of Anesthesiology and Pain Medicine Professor at the University of Washington. Dr. Raftery's research focuses on the development of new methods and applications in the field of metabolite profiling, using a combination of mass spectrometry (MS) and NMR platforms to provide a broad based approach for biomarker discovery and systems biology research. His group has recently developed methods to improve quantitative metabolomics using NMR spectroscopy, and a new targeted MS approach called globally optimized targeted (GOT)-MS with broad metabolite coverage and excellent reproducibility. Several of these approaches have been applied to the discovery of biomarkers for the early detection of colorectal cancer, including a new statistical analysis approach that aims to better incorporate clinical factors that can affect metabolite signal levels and thus improve biomarker performance.